Rv2932 - phenolpthiocerol synthesis type-I polyketide synthase ppsB

Expression: Most Significant Conditions for Rv2932

Protein Domains

Gene Information
Locus	Rv2932
Symbol	ppsB
Gene Name	phenolpthiocerol synthesis type-I polyketide synthase ppsB
Location	3251072 - 3255688 (+)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:4617 bp Protein:1539 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	25808
Related Genes	Mkms_2878 Mkms_2879 ML2356 ML2357 ML2358 Mmcs_2834 Mmcs_2835 MSMEG_6767 MT2999 MT3000 MT3002 MT3003 MUL_2018 MUL_2019 MUL_2020 Mvan_3125 Mvan_3126 Mvan_3128 Rv2930 Rv2931 Rv2933
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv2932
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv2932 Transcript 1
MMRTAFSRISGMTAQQRTSLADEFDRVSRIAVAEPVAVVGIGCRFPGDVDGPESFWDFLV
AGRNAISTVPADRWDAEAFYHPDPLTPGRMTTKWGGFVPDVAGFDAEFFGITPREAAAMD
PQQRMLLEVAWEALEHAGIPPDSLGGTRTAVMMGVYFNEYQSMLAASPQNVDAYSGTGNA
HSITVGRISYLLGLRGPAVAVDTACSSSLVAVHLACQSLRLRETDLALAGGVSITLRPET
QIAISAWGLLSPQGRCAAFDAAADGFVRGEGAGVVVLKRLTDAVRDGDQVLAVVRGSAVN
QDGRSNGVTAPNTAAQCDVIADALRSGDVAPDSVNYVEAHGTGTVLGDPIEFEALAATYG
HGGDACALGAVKTNIGHLEAAAGIAGFIKATLAVQRATIPPNLHFSQWNPAIDAASTRFF
VPTQNSPWPTAEGPRRAAVSSFGLGGTNAHVIIEQGSELAPVSEGGEDTGVSTLVVTGKT
AQRMAATAQVLADWMEGPGAEVAVADVAHTVNHHRARQATFGTVVARDRAQAIAGLRALA
AGQHAPGVVSHQDGSPGPGTVFVYSGRGSQWAGMGRQLLADEPAFAAAVAELEPVFVEQA
GFSLRDVIATGKELVGIEQIQLGLIGMQLTLTELWRSYGVQPDLVIGHSMGEVAAAVVAG
ALTPAEGLRVTATRARLMAPLSGQGGMALLGLDAAATEALIADYPQVTVGIYNSPRQTVI
AGPTEQIDELIARVRAQNRFASRVNIEVAPHNPAMDALQPAMRSELADLTPRTPTIGIIS
TTYADLHTQPIFDAEHWATNMRNPVRFQQAIASAGSGADGAYHTFIEISAHPLLTQAIAD
TLEDAHRPTKSAAKYLSIGTLQRDADDTVTFRTNLYTADIAHPPHTCHPPEPHPTIPTTP
WQHTHHWIATTHPSTAAPEDPGSNKVVVNGQSTSESRALEDWCHQLAWPIRPAVSADPPS
TAAWLVVADNELCHELARAADSRVDSLSPPALAAGSDPAALLDALRGVDNVLYAPPVPGE
LLDIESAYQVFHATRRLAAAMVASSATAISPPKLFIMTRNAQPISEGDRANPGHAVLWGL
GRSLALEHPEIWGGIIDLDDSMPAELAVRHVLTAAHGTDGEDQVVYRSGARHVPRLQRRT
LPGKPVTLNADASQLVIGATGNIGPHLIRQLARMGAKTIVAMARKPGALDELTQCLAATG
TDLIAVAADATDPAAMQTLFDRFGTELPPLEGIYLAAFAGRPALLSEMTDDDVTTMFRPK
LDALALLHRRSLKSPVRHFVLFSSVSGLLGSRWLAHYTATSAFLDSFAGARRTMGLPATV
VDWGLWKSLADVQKDATQISAESGLQPMADEVAIGALPLVMNPDAAVATVVVAADWPLLA
AAYRTRGALRIVDDLLPAPEDVGKGESEFRTSLRSCPAEKRRDMLFDHVGALAATVMGMP
PTEPLDPSAGFFQLGMDSLMSVTLQRALSESLGEFLPASVVFDYPTVYSLTDYLATVLPE
LLEIGATAVATQQATDSYHELTEAELLEQLSERLRGTQ*

Genomic Sequence

>Rv2932
GTGATGCGAACGGCTTTCAGCCGGATTTCCGGTATGACCGCGCAACAGCGCACCTCCCTA
GCCGACGAGTTCGACAGGGTCTCTCGCATCGCCGTGGCCGAGCCGGTTGCGGTGGTTGGC
ATCGGCTGCCGCTTTCCGGGAGATGTGGATGGACCAGAGAGTTTCTGGGACTTTCTGGTC
GCGGGCAGGAATGCGATCTCGACGGTGCCGGCAGATCGATGGGACGCAGAAGCGTTTTAC
CACCCCGACCCGCTAACACCGGGGCGGATGACGACGAAGTGGGGCGGCTTCGTCCCTGAC
GTCGCGGGCTTCGACGCCGAATTCTTCGGTATCACACCGCGGGAAGCCGCGGCGATGGAC
CCGCAGCAGCGAATGCTGCTGGAGGTTGCCTGGGAAGCACTCGAACATGCCGGCATACCA
CCGGATTCCCTCGGCGGCACCCGAACCGCCGTCATGATGGGGGTCTATTTCAACGAGTAT
CAGTCCATGTTGGCCGCCAGTCCGCAGAACGTAGACGCCTACAGCGGGACCGGAAATGCA
CACAGCATCACGGTGGGTCGCATCTCCTACCTGTTGGGATTACGGGGTCCGGCGGTCGCG
GTGGACACCGCCTGCTCGTCGTCGTTGGTGGCTGTGCACCTGGCGTGTCAGAGTCTGAGG
CTGCGCGAGACCGATCTGGCTCTCGCCGGTGGAGTGAGTATCACCCTTCGCCCAGAGACC
CAAATCGCTATCTCTGCCTGGGGATTGCTGTCCCCGCAGGGCCGGTGTGCCGCATTCGAT
GCGGCGGCAGACGGATTTGTGCGCGGTGAGGGCGCCGGAGTGGTAGTGCTCAAGCGGTTG
ACGGACGCGGTGCGCGACGGCGACCAGGTGCTGGCGGTGGTGCGCGGTTCGGCAGTCAAC
CAGGACGGCAGGTCCAATGGCGTAACGGCGCCGAATACGGCAGCCCAGTGCGATGTGATC
GCCGATGCCTTGCGATCCGGCGATGTGGCGCCTGACAGCGTGAATTACGTAGAGGCCCAT
GGAACCGGCACGGTGCTGGGCGACCCGATCGAATTCGAGGCCCTGGCCGCCACGTATGGC
CACGGCGGGGACGCATGCGCGTTGGGTGCGGTGAAAACCAACATCGGTCATCTGGAGGCG
GCCGCCGGGATCGCGGGGTTCATCAAGGCGACGCTGGCGGTACAACGCGCGACGATCCCG
CCGAATCTGCATTTCTCGCAATGGAATCCAGCTATCGATGCCGCGTCGACCAGGTTTTTC
GTTCCCACGCAGAACTCCCCGTGGCCAACCGCGGAGGGGCCGCGCCGGGCGGCGGTGTCG
TCGTTCGGATTGGGCGGGACGAACGCACACGTGATCATCGAGCAAGGTAGCGAGCTGGCT
CCGGTATCCGAAGGCGGCGAGGACACCGGGGTGTCGACGTTGGTGGTGACGGGTAAGACG
GCCCAGCGGATGGCCGCGACGGCGCAGGTGCTGGCCGACTGGATGGAAGGTCCGGGCGCC
GAGGTGGCCGTAGCTGATGTCGCCCACACGGTCAACCATCACCGGGCCCGCCAAGCCACG
TTCGGCACCGTCGTAGCCCGTGACCGCGCCCAGGCGATAGCCGGACTGCGCGCGCTGGCC
GCCGGCCAACACGCTCCCGGAGTGGTGAGCCACCAGGACGGTTCGCCGGGGCCGGGCACC
GTATTCGTCTACTCCGGCCGCGGCTCGCAGTGGGCCGGGATGGGTCGCCAATTGTTGGCC
GACGAGCCGGCTTTCGCCGCCGCGGTCGCCGAGCTGGAACCGGTGTTTGTCGAGCAAGCC
GGCTTCTCGCTGCGCGACGTGATCGCCACCGGCAAGGAGCTAGTCGGTATCGAGCAGATC
CAGCTTGGCCTGATCGGCATGCAACTGACATTGACTGAGCTATGGCGCTCCTACGGGGTG
CAGCCCGACCTGGTGATCGGCCACTCCATGGGCGAGGTGGCCGCCGCCGTGGTCGCCGGA
GCGCTGACTCCGGCCGAGGGTCTGCGGGTGACCGCCACCCGCGCACGGTTGATGGCGCCA
TTGTCCGGCCAGGGCGGCATGGCACTGCTGGGACTCGATGCTGCGGCCACCGAAGCGTTA
ATCGCGGACTACCCGCAGGTGACAGTGGGGATCTACAACTCGCCGCGGCAGACCGTGATC
GCCGGGCCGACCGAACAAATCGATGAGTTGATCGCCCGGGTGCGCGCGCAAAACCGGTTT
GCCAGTCGGGTCAATATCGAAGTCGCCCCGCACAATCCGGCCATGGATGCGCTGCAGCCG
GCGATGCGTTCGGAGCTGGCCGATCTGACCCCACGGACCCCCACCATCGGAATCATCTCC
ACCACCTACGCAGACTTGCACACCCAACCGATCTTCGACGCCGAACACTGGGCCACCAAC
ATGCGCAACCCCGTGCGCTTCCAGCAGGCCATCGCTTCCGCCGGTAGCGGCGCCGACGGC
GCCTACCACACCTTCATCGAGATCAGCGCACACCCGCTGCTGACCCAGGCGATTGCCGAC
ACCTTGGAAGACGCGCACCGCCCAACCAAGTCCGCAGCGAAATACTTGAGCATTGGCACC
TTGCAGCGTGATGCCGATGACACGGTCACCTTCCGCACCAACCTCTACACCGCCGACATC
GCCCACCCACCGCATACCTGTCACCCGCCCGAGCCGCACCCCACCATCCCCACCACACCC
TGGCAACACACCCACCACTGGATCGCCACCACGCACCCGAGCACGGCAGCGCCAGAAGAT
CCGGGCAGCAATAAGGTTGTGGTGAACGGACAATCGACATCCGAGAGCCGTGCGCTCGAA
GACTGGTGCCACCAGCTGGCCTGGCCGATCCGCCCGGCAGTCAGCGCCGACCCGCCCAGC
ACCGCCGCCTGGCTCGTGGTGGCAGACAACGAACTCTGCCACGAGCTGGCCCGTGCGGCC
GATTCTCGGGTAGACAGCCTCTCGCCGCCGGCGCTCGCAGCAGGCAGCGATCCGGCCGCA
CTGCTCGACGCGCTGCGCGGTGTGGACAACGTGCTCTACGCTCCACCCGTCCCCGGTGAA
CTCCTCGATATTGAATCGGCCTACCAGGTTTTCCACGCAACGCGACGGCTAGCCGCCGCG
ATGGTCGCCAGCAGCGCCACGGCTATTTCCCCGCCGAAGTTGTTCATCATGACCCGCAAC
GCCCAGCCCATCTCGGAAGGCGACCGAGCCAACCCTGGCCACGCTGTGCTGTGGGGTCTC
GGCCGGTCGCTGGCACTAGAGCATCCTGAAATCTGGGGCGGCATAATCGATCTTGACGAT
TCGATGCCCGCAGAGCTGGCCGTGCGGCATGTGCTGACTGCAGCCCACGGTACCGACGGG
GAGGATCAGGTCGTATACCGGTCGGGCGCACGCCATGTACCCCGGCTGCAGAGGCGAACT
CTTCCGGGGAAACCGGTCACGTTGAATGCCGACGCCAGCCAGCTCGTCATCGGTGCGACC
GGCAACATCGGACCGCATCTCATCCGACAGCTCGCGCGGATGGGGGCTAAGACAATCGTC
GCGATGGCTCGCAAGCCCGGCGCGCTCGACGAGTTGACCCAATGTCTCGCTGCGACCGGA
ACAGATCTCATCGCGGTGGCCGCCGATGCGACCGATCCCGCCGCCATGCAAACCCTGTTC
GACCGATTCGGCACGGAGCTACCGCCACTGGAGGGAATCTATCTGGCGGCCTTTGCGGGC
CGCCCAGCGCTGCTGAGCGAGATGACCGACGACGACGTGACCACCATGTTTCGTCCCAAG
TTGGACGCCTTGGCGTTGTTGCACCGACGGTCACTGAAGAGCCCAGTGCGCCACTTCGTT
TTGTTCTCTTCGGTGTCAGGTCTGCTGGGTTCTCGATGGCTCGCCCATTACACCGCGACC
AGCGCCTTCCTGGACAGCTTCGCCGGCGCGCGTCGCACCATGGGCCTGCCGGCCACCGTC
GTCGACTGGGGACTGTGGAAGTCGCTGGCCGATGTGCAAAAAGACGCGACTCAAATCAGC
GCGGAATCCGGGCTGCAACCCATGGCTGACGAGGTGGCCATCGGCGCGCTACCGCTGGTG
ATGAACCCCGATGCGGCAGTCGCGACCGTGGTGGTTGCCGCGGACTGGCCCTTGTTGGCC
GCGGCATATCGAACGCGGGGAGCCCTTCGCATAGTCGACGACCTGTTGCCGGCACCGGAA
GACGTCGGGAAGGGCGAAAGCGAATTCCGCACATCGTTGCGTAGCTGCCCGGCGGAGAAA
CGACGGGACATGTTGTTCGACCATGTGGGCGCCTTGGCCGCCACGGTGATGGGAATGCCG
CCCACGGAGCCGCTCGATCCGTCGGCCGGCTTCTTCCAACTCGGCATGGACTCGCTAATG
AGCGTGACACTTCAGCGGGCGTTGTCGGAAAGCCTGGGCGAGTTCTTGCCGGCGTCCGTG
GTTTTCGACTATCCGACCGTTTACAGCCTCACCGACTACCTGGCCACCGTCCTGCCTGAG
CTCCTCGAAATTGGGGCAACCGCAGTCGCAACCCAGCAAGCCACCGACTCCTACCACGAA
CTGACCGAAGCCGAGTTGTTGGAACAACTTTCGGAACGACTAAGAGGAACACAATGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Term	TBRXN:PREPTHS2 phenolic phthiocerol precursor synthesis - IDA	active	njamshidi	2012-10-05
	see PMID: 12031661, 9201977, 15668773 A. Rao & A. Ranganathan Interaction studies on proteins encoded by the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Mol. Genet. Genomics 2004
Term	TBRXN:PREPTHS2 phenolic phthiocerol precursor synthesis - IDA	active	njamshidi	2012-10-05
	see PMID: 12031661, 9201977, 15668773 authors,AK. Azad,TD. Sirakova,ND. Fernandes,PE. Kolattukudy Gene knockout reveals a novel gene cluster for the synthesis of a class of cell wall lipids unique to pathogenic mycobacteria. J. Biol. Chem. 1997
Term	TBRXN:PREPTHS2 phenolic phthiocerol precursor synthesis - IDA	active	njamshidi	2012-10-05
	see PMID: 12031661, 9201977, 15668773 authors,DE. Minnikin,L. Kremer,LG. Dover,GS. Besra The methyl-branched fortifications of Mycobacterium tuberculosis. Chem. Biol. 2002
Term	TBRXN:PREPTHS phthiocerol precursor synthesis - IDA	active	njamshidi	2012-10-05
	see PMID: 12031661, 9201977, 15668773 A. Rao & A. Ranganathan Interaction studies on proteins encoded by the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Mol. Genet. Genomics 2004
Term	TBRXN:PREPTHS phthiocerol precursor synthesis - IDA	active	njamshidi	2012-10-05
	see PMID: 12031661, 9201977, 15668773 authors,AK. Azad,TD. Sirakova,ND. Fernandes,PE. Kolattukudy Gene knockout reveals a novel gene cluster for the synthesis of a class of cell wall lipids unique to pathogenic mycobacteria. J. Biol. Chem. 1997
Term	TBRXN:PREPTHS phthiocerol precursor synthesis - IDA	active	njamshidi	2012-10-05
	see PMID: 12031661, 9201977, 15668773 authors,DE. Minnikin,L. Kremer,LG. Dover,GS. Besra The methyl-branched fortifications of Mycobacterium tuberculosis. Chem. Biol. 2002
Interaction	PhysicalInteraction Rv2939	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,JS. Cox,B. Chen,M. McNeil,WR. Jacobs Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 1999
Interaction	PhysicalInteraction Rv2939	active	shahanup86	2012-10-05
	Operon (Functional linkage) LR. Camacho, P. Constant et al. Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier. J. Biol. Chem. 2001
Interaction	PhysicalInteraction Rv2935	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,JS. Cox,B. Chen,M. McNeil,WR. Jacobs Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 1999
Interaction	PhysicalInteraction Rv2935	active	shahanup86	2012-10-05
	Operon (Functional linkage) LR. Camacho, P. Constant et al. Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier. J. Biol. Chem. 2001
Interaction	PhysicalInteraction Rv2934	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,JS. Cox,B. Chen,M. McNeil,WR. Jacobs Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 1999
Interaction	PhysicalInteraction Rv2934	active	shahanup86	2012-10-05
	Operon (Functional linkage) LR. Camacho, P. Constant et al. Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier. J. Biol. Chem. 2001
Interaction	PhysicalInteraction Rv2933	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,JS. Cox,B. Chen,M. McNeil,WR. Jacobs Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 1999
Interaction	PhysicalInteraction Rv2933	active	shahanup86	2012-10-05
	Operon (Functional linkage) LR. Camacho, P. Constant et al. Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier. J. Biol. Chem. 2001
Interaction	PhysicalInteraction Rv2939	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,JS. Cox,B. Chen,M. McNeil,WR. Jacobs Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 1999
Interaction	PhysicalInteraction Rv2938	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,JS. Cox,B. Chen,M. McNeil,WR. Jacobs Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 1999
Interaction	PhysicalInteraction Rv2937	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,JS. Cox,B. Chen,M. McNeil,WR. Jacobs Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 1999
Interaction	PhysicalInteraction Rv2936	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,JS. Cox,B. Chen,M. McNeil,WR. Jacobs Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 1999
Interaction	PhysicalInteraction Rv2935	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,JS. Cox,B. Chen,M. McNeil,WR. Jacobs Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 1999
Interaction	PhysicalInteraction Rv2934	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,JS. Cox,B. Chen,M. McNeil,WR. Jacobs Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 1999
Interaction	PhysicalInteraction Rv2933	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,JS. Cox,B. Chen,M. McNeil,WR. Jacobs Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 1999
Interaction	PhysicalInteraction Rv2931	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,JS. Cox,B. Chen,M. McNeil,WR. Jacobs Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 1999
Interaction	PhysicalInteraction Rv2930	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,JS. Cox,B. Chen,M. McNeil,WR. Jacobs Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 1999
Interaction	PhysicalInteraction Rv2939	active	shahanup86	2012-10-05
	Operon (Functional linkage) LR. Camacho, P. Constant et al. Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier. J. Biol. Chem. 2001
Interaction	PhysicalInteraction Rv2938	active	shahanup86	2012-10-05
	Operon (Functional linkage) LR. Camacho, P. Constant et al. Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier. J. Biol. Chem. 2001
Interaction	PhysicalInteraction Rv2937	active	shahanup86	2012-10-05
	Operon (Functional linkage) LR. Camacho, P. Constant et al. Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier. J. Biol. Chem. 2001
Interaction	PhysicalInteraction Rv2936	active	shahanup86	2012-10-05
	Operon (Functional linkage) LR. Camacho, P. Constant et al. Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier. J. Biol. Chem. 2001
Interaction	PhysicalInteraction Rv2935	active	shahanup86	2012-10-05
	Operon (Functional linkage) LR. Camacho, P. Constant et al. Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier. J. Biol. Chem. 2001
Interaction	PhysicalInteraction Rv2934	active	shahanup86	2012-10-05
	Operon (Functional linkage) LR. Camacho, P. Constant et al. Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier. J. Biol. Chem. 2001
Interaction	PhysicalInteraction Rv2933	active	shahanup86	2012-10-05
	Operon (Functional linkage) LR. Camacho, P. Constant et al. Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier. J. Biol. Chem. 2001
Interaction	PhysicalInteraction Rv2931	active	shahanup86	2012-10-05
	Operon (Functional linkage) LR. Camacho, P. Constant et al. Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier. J. Biol. Chem. 2001
Interaction	PhysicalInteraction Rv2930	active	shahanup86	2012-10-05
	Operon (Functional linkage) LR. Camacho, P. Constant et al. Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier. J. Biol. Chem. 2001
Interaction	Regulatory Rv3692	active	ashwinigbhat	2012-10-05
	One hybrid System DM. Collins, B. Skou et al. Generation of attenuated Mycobacterium bovis strains by signature-tagged mutagenesis for discovery of novel vaccine candidates. Infect. Immun. 2005
Interaction	Regulatory Rv3416	active	ashwinigbhat	2012-10-05
	One hybrid System DM. Collins, B. Skou et al. Generation of attenuated Mycobacterium bovis strains by signature-tagged mutagenesis for discovery of novel vaccine candidates. Infect. Immun. 2005
Interaction	Regulatory Rv2745c	active	ashwinigbhat	2012-10-05
	One hybrid System DM. Collins, B. Skou et al. Generation of attenuated Mycobacterium bovis strains by signature-tagged mutagenesis for discovery of novel vaccine candidates. Infect. Immun. 2005
Interaction	Regulatory Rv2034	active	ashwinigbhat	2012-10-05
	One hybrid System DM. Collins, B. Skou et al. Generation of attenuated Mycobacterium bovis strains by signature-tagged mutagenesis for discovery of novel vaccine candidates. Infect. Immun. 2005
Interaction	Regulatory Rv0445c	active	ashwinigbhat	2012-10-05
	One hybrid System DM. Collins, B. Skou et al. Generation of attenuated Mycobacterium bovis strains by signature-tagged mutagenesis for discovery of novel vaccine candidates. Infect. Immun. 2005
Interaction	Regulatory Rv0117	active	ashwinigbhat	2012-10-05
	One hybrid System DM. Collins, B. Skou et al. Generation of attenuated Mycobacterium bovis strains by signature-tagged mutagenesis for discovery of novel vaccine candidates. Infect. Immun. 2005
Interaction	Regulatory Rv3692	active	ashwinigbhat	2012-10-05
	One hybrid System M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	Regulatory Rv3416	active	ashwinigbhat	2012-10-05
	One hybrid System M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	Regulatory Rv2745c	active	ashwinigbhat	2012-10-05
	One hybrid System M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	Regulatory Rv2034	active	ashwinigbhat	2012-10-05
	One hybrid System M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	Regulatory Rv0445c	active	ashwinigbhat	2012-10-05
	One hybrid System M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	Regulatory Rv0117	active	ashwinigbhat	2012-10-05
	One hybrid System M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	PhysicalInteraction Rv2931	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,JS. Cox,B. Chen,M. McNeil,WR. Jacobs Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 1999
Interaction	PhysicalInteraction Rv2931	active	shahanup86	2012-10-05
	Operon (Functional linkage) LR. Camacho, P. Constant et al. Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier. J. Biol. Chem. 2001
Interaction	PhysicalInteraction Rv2930	active	shahanup86	2012-10-05
	Operon (Functional linkage) authors,JS. Cox,B. Chen,M. McNeil,WR. Jacobs Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 1999
Interaction	PhysicalInteraction Rv2930	active	shahanup86	2012-10-05
	Operon (Functional linkage) LR. Camacho, P. Constant et al. Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier. J. Biol. Chem. 2001
Interaction	RegulatedBy Rv3911	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. S. Raman, X. Puyang et al. Mycobacterium tuberculosis SigM positively regulates Esx secreted protein and nonribosomal peptide synthetase genes and down regulates virulence-associated surface lipid synthesis. J. Bacteriol. 2006
Interaction	RegulatedBy Rv3692	active	yamir.moreno	2012-10-05
	One hybrid reporter system. Physical binding of the regulator to the regulated promoter proved by using electrophoretic mobility shift assay. . M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	RegulatedBy Rv3416	active	yamir.moreno	2012-10-05
	One hybrid reporter system. Physical binding of the regulator to the regulated promoter proved by using electrophoretic mobility shift assay. . M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	RegulatedBy Rv2745c	active	yamir.moreno	2012-10-05
	One hybrid reporter system. Physical binding of the regulator to the regulated promoter proved by using electrophoretic mobility shift assay. . M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	RegulatedBy Rv1956	active	yamir.moreno	2012-10-05
	One hybrid reporter system. Physical binding of the regulator to the regulated promoter proved by using electrophoretic mobility shift assay. . M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	RegulatedBy Rv1359	active	yamir.moreno	2012-10-05
	One hybrid reporter system. Physical binding of the regulator to the regulated promoter proved by using electrophoretic mobility shift assay. . M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	RegulatedBy Rv0445c	active	yamir.moreno	2012-10-05
	One hybrid reporter system. Physical binding of the regulator to the regulated promoter proved by using electrophoretic mobility shift assay. . M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	RegulatedBy Rv0117	active	yamir.moreno	2012-10-05
	One hybrid reporter system. Physical binding of the regulator to the regulated promoter proved by using electrophoretic mobility shift assay. . M. Guo, H. Feng et al. Dissecting transcription regulatory pathways through a new bacterial one-hybrid reporter system. Genome Res. 2009
Interaction	RegulatedBy Rv0981	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. H. He, R. Hovey et al. MprAB is a stress-responsive two-component system that directly regulates expression of sigma factors SigB and SigE in Mycobacterium tuberculosis. J. Bacteriol. 2006
Interaction	RegulatedBy Rv0757	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. SB. Walters, E. Dubnau et al. The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis. Mol. Microbiol. 2006
Name	Type 1 polyketide synthase responsible with PpsA-C-D-E for the elongation of C22-C24 fatty acids and p-hydroxyphenylalkanoates with malonyl-CoA and methylmalonyl-CoA to yield phthiocerol and phenolphthiocerol derivatives, respectively	active	mjackson	2012-10-05
	Phthiocerol dimycocerosates (PDIM), phenolic glycolipids (PGL) and para-hydroxybenzoic acid derivatives
Name	Type 1 polyketide synthase responsible with PpsA-C-D-E for the elongation of C22-C24 fatty acids and p-hydroxyphenylalkanoates with malonyl-CoA and methylmalonyl-CoA to yield phthiocerol and phenolphthiocerol derivatives, respectively	active	mjackson	2012-10-05
	Phthiocerol dimycocerosates (PDIM), phenolic glycolipids (PGL) and para-hydroxybenzoic acid derivatives
Other	TBPWY:Phthiocerol dimycocerosates, PGL & pHBAD	active	mjackson	2012-03-05
	Type 1 polyketide synthase responsible with PpsA-C-D-E for the elongation of C22-C24 fatty acids and p-hydroxyphenylalkanoates with malonyl-CoA and methylmalonyl-CoA to yield phthiocerol and phenolphthiocerol derivatives, respectively (phenotypic [mycobacterial recombinant strains]; enzymatic) authors,JS. Cox,B. Chen,M. McNeil,WR. Jacobs Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice. Nature 1999
Other	TBPWY:Phthiocerol dimycocerosates, PGL & pHBAD	active	mjackson	2012-03-05
	Type 1 polyketide synthase responsible with PpsA-C-D-E for the elongation of C22-C24 fatty acids and p-hydroxyphenylalkanoates with malonyl-CoA and methylmalonyl-CoA to yield phthiocerol and phenolphthiocerol derivatives, respectively (phenotypic [mycobacterial recombinant strains]; enzymatic) authors,AK. Azad,TD. Sirakova,ND. Fernandes,PE. Kolattukudy Gene knockout reveals a novel gene cluster for the synthesis of a class of cell wall lipids unique to pathogenic mycobacteria. J. Biol. Chem. 1997
Other	TBPWY:Phthiocerol dimycocerosates, PGL & pHBAD	active	mjackson	2012-03-05
	Type 1 polyketide synthase responsible with PpsA-C-D-E for the elongation of C22-C24 fatty acids and p-hydroxyphenylalkanoates with malonyl-CoA and methylmalonyl-CoA to yield phthiocerol and phenolphthiocerol derivatives, respectively (phenotypic [mycobacterial recombinant strains]; enzymatic) OA. Trivedi, P. Arora et al. Dissecting the mechanism and assembly of a complex virulence mycobacterial lipid. Mol. Cell 2005
Other	EC:	active	jjmcfadden	2012-03-05
	Inferred from direct assay P. Constant, E. Perez et al. Role of the pks15/1 gene in the biosynthesis of phenolglycolipids in the Mycobacterium tuberculosis complex. Evidence that all strains synthesize glycosylated p-hydroxybenzoic methyl esters and that strains devoid of phenolglycolipids harbor a frameshift mutation in the pks15/1 gene. J. Biol. Chem. 2002