Rv2946c - polyketide synthase pks1
Protein Domains

Gene Information
LocusRv2946c
Symbolpks1
Gene Namepolyketide synthase pks1
Location3291503 - 3296353 (-)
SpeciesMycobacterium tuberculosis H37Rv complete genome.
LengthGene:4851 bp
Protein:1617 aa
External LinksTuberculist
Target Gene Information
String Protein-Protein Interactions
STITCH Chemical-Protein Interactions
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Orthologs
Orthogroup Number31647
Related GenesCE2557 cg3003 DIP2009 jk0270 ML0132 ML0134 ML0135 MT3018 MT3021 MT3023 MUL_2002 MUL_2004 MUL_2005 nfa12430 Rv2947c Rv2948c Rv2950c
Transcriptional Regulation
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Regulatory Network
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Expression Correlation Genes with Correlated Expression
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Sequence
Proteins
Genomic Sequence
Community Annotations Pending Curatorial Review
FieldValueStatusCreatorDate
NameTogether with Pks15, type I polyketide synthase involved in the elongation of p-hydroxybenzoic acid derivatives with malonyl-CoA to form p-hydroxyphenylalkanoates (precursors of phenolic glycolipids [PGL]); the pks15 and pks1 genes are fused in PGL-producing strains of M. tuberculosis but a frameshift mutation causes this polyketide synthase to be inactive in the H37Rv strainactivemjackson2012-10-05
Phthiocerol dimycocerosates (PDIM), phenolic glycolipids (PGL) and para-hydroxybenzoic acid derivatives
OtherTBPWY:Phthiocerol dimycocerosates, PGL & pHBADactivemjackson2012-03-05
Together with Pks15, type I polyketide synthase involved in the elongation of p-hydroxybenzoic acid derivatives with malonyl-CoA to form p-hydroxyphenylalkanoates (precursors of phenolic glycolipids [PGL]); the pks15 and pks1 genes are fused in PGL-producing strains of M. tuberculosis but a frameshift mutation causes this polyketide synthase to be inactive in the H37Rv strain (phenotypic [mycobacterial recombinant strains])
P. Constant, E. Perez et al. Role of the pks15/1 gene in the biosynthesis of phenolglycolipids in the Mycobacterium tuberculosis complex. Evidence that all strains synthesize glycosylated p-hydroxybenzoic methyl esters and that strains devoid of phenolglycolipids harbor a frameshift mutation in the pks15/1 gene. J. Biol. Chem. 2002
OtherEC:activejjmcfadden2012-03-05
Inferred from direct assay
P. Constant, E. Perez et al. Role of the pks15/1 gene in the biosynthesis of phenolglycolipids in the Mycobacterium tuberculosis complex. Evidence that all strains synthesize glycosylated p-hydroxybenzoic methyl esters and that strains devoid of phenolglycolipids harbor a frameshift mutation in the pks15/1 gene. J. Biol. Chem. 2002