Rv2948c - fatty-acid-CoA ligase fadD22

Expression: Most Significant Conditions for Rv2948c

Protein Domains

Gene Information
Locus	Rv2948c
Symbol	fadD22
Gene Name	fatty-acid-CoA ligase fadD22
Location	3297837 - 3299954 (-)
Species	Mycobacterium tuberculosis H37Rv complete genome.
Length	Gene:2118 bp Protein:706 aa
External Links	Tuberculist Target Gene Information String Protein-Protein Interactions STITCH Chemical-Protein Interactions Search Google Scholar
Orthologs
Orthogroup Number	31647
Related Genes	CE2557 cg3003 DIP2009 jk0270 ML0132 ML0134 ML0135 MT3018 MT3021 MT3023 MUL_2002 MUL_2004 MUL_2005 nfa12430 Rv2946c Rv2947c Rv2950c
Transcriptional Regulation
Operons	View gene in operon browser
Regulatory Network	Search for regulators of Rv2948c
Expression Correlation	Genes with Correlated Expression Scatterplot of Gene Expression

Sequence

Proteins

>Rv2948c Transcript 1
MRNGNLAGLLAEQASEAGWYDRPAFYAADVVTHGQIHDGAARLGEVLRNRGLSSGDRVLL
CLPDSPDLVQLLLACLARGVMAFLANPELHRDDHALAARNTEPALVVTSDALRDRFQPSR
VAEAAELMSEAARVAPGGYEPMGGDALAYATYTSGTTGPPKAAIHRHADPLTFVDAMCRK
ALRLTPEDTGLCSARMYFAYGLGNSVWFPLATGGSAVINSAPVTPEAAAILSARFGPSVL
YGVPNFFARVIDSCSPDSFRSLRCVVSAGEALELGLAERLMEFFGGIPILDGIGSTEVGQ
TFVSNRVDEWRLGTLGRVLPPYEIRVVAPDGTTAGPGVEGDLWVRGPAIAKGYWNRPDSP
VANEGWLDTRDRVCIDSDGWVTYRCRADDTEVIGGVNVDPREVERLIIEDEAVAEAAVVA
VRESTGASTLQAFLVATSGATIDGSVMRDLHRGLLNRLSAFKVPHRFAVVDRLPRTPNGK
LVRGALRKQSPTKPIWELSLTEPGSGVRAQRDDLSASNMTIAGGNDGGATLRERLVALRQ
ERQRLVVDAVCAEAAKMLGEPDPWSVDQDLAFSELGFDSQMTVTLCKRLAAVTGLRLPET
VGWDYGSISGLAQYLEAELAGGHGRLKSAGPVNSGATGLWAIEEQLNKVEELVAVIADGE
KQRVADRLRALLGTIAGSEAGLGKLIQAASTPDEIFQLIDSELGK*

Genomic Sequence

>Rv2948c
ATGCGGAATGGGAATCTAGCGGGGCTCCTGGCTGAGCAGGCATCGGAGGCGGGATGGTAC
GACCGGCCGGCCTTCTATGCGGCCGATGTGGTGACTCATGGTCAAATCCACGACGGTGCC
GCACGTCTTGGGGAAGTGCTGAGAAACCGCGGACTATCCAGTGGTGATCGGGTTCTGTTG
TGCCTGCCGGATTCGCCCGACCTGGTGCAGCTATTGCTGGCGTGCCTGGCTCGTGGGGTT
ATGGCGTTTCTAGCGAATCCGGAGCTGCATCGCGACGACCACGCGTTGGCCGCACGCAAC
ACGGAACCGGCGCTTGTCGTCACCTCGGATGCGCTGCGCGATCGGTTTCAGCCGTCGCGG
GTGGCCGAAGCCGCGGAACTCATGTCCGAGGCGGCTCGAGTCGCGCCTGGAGGCTACGAA
CCGATGGGTGGTGACGCACTCGCATACGCTACGTATACGTCTGGTACCACGGGTCCGCCG
AAGGCGGCGATTCATCGGCACGCCGACCCGTTGACGTTCGTGGACGCTATGTGTCGTAAA
GCCTTGCGGCTCACTCCTGAAGATACTGGGCTATGTAGTGCACGCATGTATTTTGCTTAC
GGCCTAGGAAATTCGGTCTGGTTTCCACTCGCGACAGGTGGTTCCGCGGTCATCAATTCG
GCGCCGGTAACTCCAGAAGCAGCGGCCATTCTAAGCGCGCGATTTGGGCCATCGGTGCTC
TACGGTGTGCCAAATTTCTTTGCCAGAGTCATCGACTCATGTTCTCCTGATTCCTTCCGT
TCGCTTCGATGTGTGGTGTCAGCCGGGGAGGCCCTTGAGCTGGGTCTTGCCGAGCGGCTC
ATGGAATTCTTTGGCGGCATCCCCATTCTGGACGGTATTGGATCTACGGAGGTCGGGCAG
ACGTTCGTATCGAATCGGGTTGACGAATGGCGCCTGGGGACGCTGGGAAGGGTGCTGCCG
CCCTACGAGATTCGTGTTGTAGCGCCGGATGGAACAACTGCCGGGCCTGGGGTTGAGGGC
GACCTATGGGTCCGCGGACCGGCGATCGCTAAGGGCTATTGGAATCGGCCTGATTCCCCC
GTCGCGAATGAGGGTTGGCTCGACACGCGGGACAGGGTGTGTATCGACAGCGACGGGTGG
GTTACCTACCGCTGCCGCGCCGACGACACCGAGGTTATCGGAGGGGTCAACGTTGATCCG
CGTGAGGTCGAGCGACTCATCATCGAGGACGAAGCCGTGGCTGAGGCCGCGGTTGTCGCG
GTAAGGGAGTCCACGGGCGCGTCGACACTGCAGGCTTTTCTGGTTGCGACCAGCGGTGCC
ACCATCGATGGGTCGGTCATGCGAGACCTTCACCGCGGATTGCTCAACCGATTGTCTGCG
TTCAAGGTGCCGCATAGGTTTGCCGTTGTTGATCGACTCCCTCGAACCCCGAACGGGAAA
TTGGTGCGTGGCGCCCTGCGCAAGCAGAGTCCAACCAAACCGATTTGGGAACTCTCGTTG
ACTGAACCTGGGTCCGGCGTGCGGGCGCAGCGTGATGACCTGTCGGCGTCCAACATGACG
ATCGCCGGAGGAAACGACGGCGGGGCGACTCTTCGCGAGCGGTTGGTCGCTTTGCGGCAA
GAACGTCAGCGGCTGGTGGTGGATGCCGTATGCGCCGAGGCCGCGAAGATGTTAGGTGAG
CCAGATCCTTGGTCGGTCGATCAGGATCTCGCCTTCTCGGAGCTGGGTTTTGACTCGCAA
ATGACAGTCACGCTGTGCAAGCGATTGGCGGCAGTTACCGGCCTGCGGTTACCCGAGACG
GTTGGGTGGGACTACGGGTCGATATCGGGATTAGCCCAGTATTTGGAGGCCGAACTGGCC
GGCGGGCATGGTCGATTGAAATCAGCCGGTCCGGTGAATAGCGGCGCGACGGGTCTTTGG
GCAATCGAAGAGCAGTTGAACAAGGTCGAAGAGCTGGTGGCCGTCATCGCCGACGGCGAG
AAGCAGCGGGTGGCCGACCGTTTGCGTGCCCTGCTGGGCACCATCGCCGGCAGCGAGGCG
GGCCTGGGCAAGCTGATCCAGGCTGCTTCGACTCCTGACGAAATTTTCCAGCTAATCGAT
TCCGAACTTGGGAAGTGA

Community Annotations Pending Curatorial Review

Field	Value	Status	Creator	Date
Interaction	Operon Rv2950c	active	ashwinigbhat	2012-10-05
	Co-expression (Functional linkage) B. Abomoelak, EA. Hoye et al. mosR, a novel transcriptional regulator of hypoxia and virulence in Mycobacterium tuberculosis. J. Bacteriol. 2009
Interaction	Regulatory Rv0348	active	ashwinigbhat	2012-10-05
	Co-expression (Functional linkage) B. Abomoelak, EA. Hoye et al. mosR, a novel transcriptional regulator of hypoxia and virulence in Mycobacterium tuberculosis. J. Bacteriol. 2009
Interaction	Operon Rv2450c	active	ashwinigbhat	2012-10-05
	Co-expression (Functional linkage) B. Abomoelak, EA. Hoye et al. mosR, a novel transcriptional regulator of hypoxia and virulence in Mycobacterium tuberculosis. J. Bacteriol. 2009
Interaction	Operon Rv2949c	active	ashwinigbhat	2012-10-05
	Co-expression (Functional linkage) B. Abomoelak, EA. Hoye et al. mosR, a novel transcriptional regulator of hypoxia and virulence in Mycobacterium tuberculosis. J. Bacteriol. 2009
Interaction	RegulatedBy Rv0348	active	yamir.moreno	2012-10-05
	Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. B. Abomoelak, EA. Hoye et al. mosR, a novel transcriptional regulator of hypoxia and virulence in Mycobacterium tuberculosis. J. Bacteriol. 2009
Name	p-hydroxybenzoyl-AMP ligase involved in the biosynthesis of phenolic glycolipids; catalyzes the activation of p-hydroxybenzoic acid and its subsequent transfer onto Pks15/1 for the production of p-hydroxyphenylalkanoates	active	mjackson	2012-10-05
	Phthiocerol dimycocerosates (PDIM), phenolic glycolipids (PGL) and para-hydroxybenzoic acid derivatives
Name	p-hydroxybenzoyl-AMP ligase involved in the biosynthesis of phenolic glycolipids; catalyzes the activation of p-hydroxybenzoic acid and its subsequent transfer onto Pks15/1 for the production of p-hydroxyphenylalkanoates	active	mjackson	2012-10-05
	Phthiocerol dimycocerosates (PDIM), phenolic glycolipids (PGL) and para-hydroxybenzoic acid derivatives
Other	TBPWY:Phthiocerol dimycocerosates, PGL & pHBAD	active	mjackson	2012-03-05
	p-hydroxybenzoyl-AMP ligase involved in the biosynthesis of phenolic glycolipids; catalyzes the activation of p-hydroxybenzoic acid and its subsequent transfer onto Pks15/1 for the production of p-hydroxyphenylalkanoates (phenotypic [mycobacterial recombinant strains]; enzymatic) authors,R. Siméone,M. Léger,P. Constant,W. Malaga,H. Marrakchi,M. Daffé,C. Guilhot,C. Chalut Delineation of the roles of FadD22, FadD26 and FadD29 in the biosynthesis of phthiocerol dimycocerosates and related compounds in Mycobacterium tuberculosis. FEBS J. 2010
Other	TBPWY:Phthiocerol dimycocerosates, PGL & pHBAD	active	mjackson	2012-03-05
	p-hydroxybenzoyl-AMP ligase involved in the biosynthesis of phenolic glycolipids; catalyzes the activation of p-hydroxybenzoic acid and its subsequent transfer onto Pks15/1 for the production of p-hydroxyphenylalkanoates (phenotypic [mycobacterial recombinant strains]; enzymatic) W. He,CE. Soll,SS. Chavadi,G. Zhang,JD. Warren,LE. Quadri Cooperation between a coenzyme A-independent stand-alone initiation module and an iterative type I polyketide synthase during synthesis of mycobacterial phenolic glycolipids. J. Am. Chem. Soc. 2009
Other	TBPWY:Phthiocerol dimycocerosates, PGL & pHBAD	active	mjackson	2012-03-05
	p-hydroxybenzoyl-AMP ligase involved in the biosynthesis of phenolic glycolipids; catalyzes the activation of p-hydroxybenzoic acid and its subsequent transfer onto Pks15/1 for the production of p-hydroxyphenylalkanoates (phenotypic [mycobacterial recombinant strains]; enzymatic) JA. Ferreras, KL. Stirrett et al. Mycobacterial phenolic glycolipid virulence factor biosynthesis: mechanism and small-molecule inhibition of polyketide chain initiation. Chem. Biol. 2008